lek. Jaromir Kargol
ORCID : 0000-0002-4462-3053
The topic of my dissertation is “Endometrial cancer – what can we see on magnetic resonance images? Tumour staging and the attempt of assessment of endometrial cancer aggressiveness with magnetic resonance imaging”.
Diagnosis and treatment of patients suffering from endometrial cancer are important in modern medicine. It is the most common malignant tumour of women’s reproductive organs in developed countries. According to the data from 2018, the number of cases in Poland is 5th and deaths 7th among malignant tumours in women. In Europe, 10 to 20 in every 1000 women are expected to develop endometrial cancer during their lifetime. Over the years we have been observing an increased incidence in Europe and North America. That could be related to a greater overall prevalence of obesity and metabolic syndromes in these regions, in addition to the ageing of the population. The main risk factor is exposure to endogenous and exogenous oestrogens associated with obesity, diabetes, early age at menarche, nulliparity, late-onset menopause, older age (≥55 years), and use of tamoxifen.
Modern medicine benefits from the development of imaging methods, such as multidetector computed tomography and magnetic resonance imaging (MRI). Thanks to its high tissue contrast resolution and its reproducibility, MRI is considered the imaging modality of choice in the preoperative staging of endometrial cancer. It allows accurate assessment of the depth of myometrial invasion which is a crucial prognostic factor. Novel MRI methods such as dynamic contrast enhancement and diffusion–weighted imaging provide additional data and may provide imaging biomarkers.
To realize our investigation we will examine a group of more than 100 women and thanks to the analysis of the magnetic resonance parameters and their relationship to histopathological analysis and previously used diagnostics protocols.
Our work will allow adopting the advantages of novel imaging techniques to clinical practice. The project aims to better understand the pathophysiology of endometrial cancer. That also may improve the diagnosis and treatment of women affected by this disease. Tailored therapy may shorten the treatments’ duration and reduce complications.