mgr Dominik Wojdyła

Informacje

I am a PhD candidate in Biotechnology at the University of Rzeszów, specializing in yeast biotechnology, genetic engineering, and sustainable bioproduction. My research focuses on non-conventional yeasts, particularly Candida famata and Ogataea polymorpha, with the goal of improving the production of valuable compounds such as riboflavin using renewable raw materials, including lignocellulosic biomass.

I have experience in molecular biology, strain engineering, metabolic optimization, and fermentation processes, as well as in managing international research projects. Currently, I am the principal investigator of a National Science Centre (NCN) PRELUDIUM project aimed at optimizing riboflavin production in yeast as a platform for sustainable biotechnology. My work integrates fundamental research with applied biotechnology to develop innovative and environmentally friendly production strategies.

Research Projects

• Principal Investigator (2024–present)
  NCN PRELUDIUM 22 — Construction of Candida famata strains with improved riboflavin production on lignocellulosic hydrolysates.

• Project Manager (2023–2025)
  MSCA4Ukraine (Alexander von Humboldt Foundation) — Genetic control of lignocellulosic sugar transport and metabolism in Ogataea polymorpha.

• Researcher (2022–2023)
  PCI Project N3_053 — Development of thermotolerant Ogataea polymorpha strains for cellobiose fermentation.

• Researcher (2022)
  PCI Project N3_095 — Engineering efficient riboflavin-producing Candida famata strains on lignocellulose hydrolysates and whey

Publications

• Ruchala J., Najdecka A., Wojdyla D., Liu W., Sibirny A. (2025). Regulation of Riboflavin Biosynthesis in Microorganisms and Construction of the Advanced Overproducers of This Vitamin. International Journal of Molecular Sciences, 26(13):6243. https://doi.org/10.3390/ijms26136243

• Wojdyła D., Vasylyshyn R., Najdecka A., Ruchala J. (2025). Lignocellulosic biomass fermentation: a roadmap for Candida famata and Ogataea polymorpha. FEMS Yeast Research, 25:foaf046. https://doi.org/10.1093/femsyr/foaf046

• Ruchala J., Fedorovych D., Wojdyla D., Dmytruk K.V., Sibirny A.A. (2025). Riboflavin Overproduction in Yeasts and Filamentous Fungi. In: Sibirny A.A. (eds) Biotechnology of Yeasts and Filamentous Fungi. Grand Challenges in Biology and Biotechnology. Springer, Cham. https://doi.org/10.1007/978-3-031-74726-7_9

• Dzanaeva L.S., Wojdyła D., Fedorovych D.V., Ruchala J., Dmytruk K.V., Sibirny A.A. (2024). Riboflavin overproduction on lignocellulose hydrolysate by the engineered yeast Candida famata. FEMS Yeast Research, 24:foae020.

• Mołoń M., Zaciura M., Wojdyła D., Molestak E. (2023). Increasing the number of ribosomal uL6 mRNA copies accelerates aging of the budding yeast. Molecular Biology Reports, 50(3), 2933–2941.

• Stępień K., Wojdyła D., Nowak K., Mołoń M. (2020). Impact of curcumin on replicative and chronological aging in the Saccharomyces cerevisiae yeast. Biogerontology, 21(1), 109–123.

• Wojdyła D., Stępień K., Ciak B., Mołoń M. (2019). Rola stresu oksydacyjnego w starzeniu się drożdży Saccharomyces cerevisiae. In: Danielewska A., Maciąg M. (eds) Wybrane zagadnienia z zakresu mikrobiologii. Wydawnictwo Naukowe TYGIEL, Lublin, 17–30.

• Stępień K., Wojdyła D., Nowak K., Mołoń M. (2019). Wykorzystanie drożdży pączkujących Saccharomyces cerevisiae w badaniach nad wpływem restrykcji kalorycznej na aktywność metaboliczną i starzenie komórek. In: Danielewska A., Maciąg M. (eds) Wybrane zagadnienia z zakresu mikrobiologii. Wydawnictwo Naukowe TYGIEL, Lublin, 31–38.