Cell size regulation
Title: Regulators of cell size, reproductive potential and cell lifespan
Supervisor: Renata Zadrąg-Tęcza, PhD, DSc, e-mail: retecza@ur.edu.pl
Short description:
Cell size affects the biosynthetic processes and thus the physiological efficiency of the cell. Hence, the cell size is an important determinant of its reproductive capacity and may also affect the post-reproductive lifespan. The studies conducted on the S. cerevisiae yeast cells have shown that achieving an excessive size (hypertrophy state) prevents the cell from further proliferation.
The purpose of the research focusing on this topic is to determine the nature of the relationship between cell size, reproductive potential and post-reproductive time of life, and thus the search for answer to question whether and to what extent the factors determining the cell reproductive capacity also affect on the post-reproductive phase of the cell's life.
The implementation of the research goal will be based on a comprehensive analysis of cells, showing their physiological efficiency which, combined with the analysis of cell size, reproductive potential and duration of the post-reproductive phase, will help create a model of interaction between each of these elements.
Competences:
- knowledge of biochemistry and cell biology as well as knowledge of basic techniques of cell biology, biochemistry and molecular biology,
- ability to verification and description of the results for publication and presentation at scientific conferences,
- knowledge of the principles of laboratory work.