lek. Ewelina Mazur

ORCID: 0000-0003-2329-6863

The topic of my dissertation is "Assessment of the influence of normobaric hyperoxia on the psoriasis course and patients well-being".

My research focuses on broadening the knowledge about the influence of normobaric hyperoxia (HBOT) on the skin condition and well-being of patients with different dermatological conditions e.g. psoriasis. I assess the effect of therapy on the change of disease severity indices, patient well-being indicators, as well as change in the concentration of pro-inflammatory cytokines. Historically, the use of hyperoxia has been associated with the occurrence of local and general side effects, including lung damage, resorptive atelectasis, increased production of free oxygen radicals, vasoconstriction, or altered cellular metabolism. However, recent scientific reports indicate the potential therapeutic role of increased oxygen concentrations in normobaric conditions. Several studies have shown that hyperoxia improves neurological outcomes in ischemic strokes and reduces the inflammatory response in sepsis or ischemia-reperfusion conditions. It has been proven that normobaric hyperoxia may decrease the concentration of interleukin-6, interleukin-1B, and tumor necrosis factor, which are involved in the processes of keratinocyte hyperstimulation. By reduction of pro-inflammatory cytokines that influence keratinocyte hyperstimulation, HBOT may contribute to the improvement of psoriasis. So far, however, no studies have been conducted under the conditions of normobaric hyperoxia among patients with dermatological diseases.

International projects: “ Definition of Severity and Descriptors of Chronic Prurigo - Harmonization of European Prurigo Documentation (EPD Project)”.

Publications:

  1. Czy test Montreal Cognitive Assessment (MoCA) może być skuteczniejszy od powszechnie stosowanego Mini-Mental State Examination (MMSE) w wykrywaniu łagodnych zaburzeń funkcji poznawczych u osób po 60. roku życia?, Psychiatria Polska, 2016; 50(5), s. 1039–1052, PL ISSN 0033-2674 (PRINT), ISSN 2391-5854; DOI: https://doi.org/10.12740/PP/45368
  2. Porównanie skuteczności Montreal Cognitive Assessment 7.2 z Mini-Mental State Examination w wykrywaniu łagodnych zaburzeń neuropoznawczych u osób po 60 roku życia. Doniesienia wstępne. PP-00067-2016-02, Psychiatria Polska” 2018; 52(5), s. 843–857, PL ISSN 0033-2674 (PRINT), ISSN 2391-5854 (ONLINE), www.psychiatriapolska.pl; DOI: https://doi.org/10.12740/PP/68611
  3. Impact of resveratrol on exercise performance: A review „Science & Sports” 2018; 33(4), s. 207-212; DOI:10.1016/j.scispo.2018.02.010
  4. Carbamazepine - hematologic effects of the use, „Journal of Education, Health and Sport”, 2018, 8(8), s. 51-60. eISNN 2391-8306, DOI http://dx.doi.org/10.5281/zenodo.1296993
  5. Cardiac amyloidosis: a review, „Journal of Education, Health and Sport”, 2019, 9(3), s. 333-338. eISNN 2391-8306. DOI http://dx.doi.org/zenodo.2597569
  6. METALLO-BETA-LACTAMASES: NDM. „Journal of Education, Health and Sport”, 2019, 9(6), s. 27-40. eISNN 2391-8306, DOI http://dx.doi.org/10.5281/zenodo.3236053
  7. Systemic lupus erythematosus of the urinary tract: focus on lupus cystitis, „Reumatologia”, 2018, 56, 4, s. 255–258, DOI: https://doi.org/10.5114/reum.2018.77978
  8. Evaluation of young adults' attitudes towards the elderly Ocena postaw młodych dorosłych wobec osób w podeszłym wieku, „Gerontologia Polska”, 2018, 26, s. 239-245.
  9. Endocrine systems of the skin. Postępy Dermatologii i Alergologii 2019, 36(5), s. 519-523, DOI: 10.5114/ada.2019.89502